Etiology and antimicrobial susceptibility profile in neonatal sepsis
DOI:
https://doi.org/10.37135/ee.04.13.02Keywords:
Sepsis, Neonate, AntimicrobialAbstract
Neonatal sepsis is a major cause of morbidity and mortality. The investigative process was carried out to describe the etiology and antimicrobial susceptibility pattern of the bacteria most frequently isolated from blood cultures of neonates with sepsis in the neonatology service of the Ambato General Teaching Hospital. The methodology used in this research was based on a descriptive, cross-sectional study and a quali-quantitative approach, using the documentary technique and the report of results as an instrument. 39 patients were studied, 64.10% of them were male. 23.07% had low weight and 33.33% had a gestational age <37 weeks. The most frequent microorganism was Staphylococcus epidermidis (51.28%), followed by Escherichia coli (17.94%) and Staphylococcus aureus (15.38%). In relation to the antimicrobial susceptibility profile, S. epidermidis and S. aureus were sensitive to linezolid and vancomycin in more than 80.00% and presented high resistance to oxacillin (80.00 and 83.33%, respectively), these strains phenotypically expressed the mecA gene. Isolated Enterobacteriaceae showed resistance to amoxacillin / clavulanic acid (61.53%), ampicillin / sulbactam (69.23%), ciprofloxacin (61.53%), ceftazidime (30.76%) and cefotaxime (38.46%). Furthermore, five strains of E. coli and Klebsiella pneumoniae were phenotypically producers of extended spectrum beta lactamases. In conclusion, it is necessary to perform local microbiological surveillance studies in hospitals to identify multi-resistant pathogens involved in neonatal infections, recognize outbreaks, and monitor the changes that occur over time, which influence the choice of empirical treatments.
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