Hyperglycemia and mean platelet volume as early predictors of acute coronary syndrome type IAM SEST
DOI:
https://doi.org/10.37135/ee.004.06.01Keywords:
thoracic pain, hyperglycemia, medium platelet volume, acute coronary syndromeAbstract
Introduction: the aim of this research is to determine the diagnostic validity of hyperglycemia and mean platelet volume in the early diagnosis of patients who come to the Emergency Department with chest pain and suspected acute myocardial infarction without ST elevation. Materials and methods: an uncontrolled clinical trial was conducted to validate diagnostic tests of 6 months in 133 patients admitted to the Emergency Department of the Carlos Andrade Marín Hospital for chest pain and suspected acute coronary syndrome. A cohort point of hyperglycemia> 140 mg / dl and mean platelet volume ≥ 10.33 fl upon admission was considered taking into account values proposed in the ROC curve (receiver operant curve); as well as, the diagnostic performance of the tests, univariate and multivariate regression was determined. Results: of the 133 patients included in the study, 32 (24.1%) had acute myocardial infarction without ST elevation. The diagnostic yield of mean platelet volume ≥ 10.33 fl (AUC: 0.91, 95% CI: 0.841-0.979, p <0.05) had a sensitivity of 81.2%, specificity of 93.1%, value positive predictive 78.8%, negative predictive value 94%, positive likelihood ratio 11.723 and negative likelihood ratio 0.201. For hyperglycemia> 140 mg / dL (AUC: 0.923, 95% CI: 0.879-0.967, p <0.05) the sensitivity was 71.9%, specificity 90.1%, positive predictive value 69.7%, negative predictive value 91%, positive likelihood ratio 7,259 and negative likelihood ratio 0,312. Conclusion: hyperglycaemia and mean platelet volume are biomarkers with good predictive capacity for the early diagnosis of acute myocardial infarction without ST elevation.
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