COVID-19: epidemiología, virología y transmisibilidad
DOI:
https://doi.org/10.37135/ee.04.12.10Palabras clave:
COVID-19, SARS-CoV-2, coronavirus, epidemiología, virologíaResumen
Hasta diciembre del 2019, seis tipos de coronavirus ya estaban identificados como generadores de enfermedad en humanos, destacándose dos brotes epidemiológicos anteriores: SARS-CoV en 2002 y MERS-CoV en 2012. El nuevo agente infeccioso que causó la pandemia de 2019 se denominó SARS-CoV-2, el que se manifiesta como un síndrome respiratorio agudo severo (COVID-19). Al respecto, el 30 de enero del 2020, la Organización Mundial de la Salud (OMS) decretó la emergencia sanitaria. El propósito de esta revisión fue analizar el contexto epidemiológico alrededor del SARS-CoV-2, mediante una búsqueda bibliográfica en las bases de datos científicas como: PubMed Central, LILACS y Google académico. Se concluyó que el SARS-CoV-2 es altamente transmisible, con una tasa de letalidad en Ecuador del 8,59%.
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Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. Dis [Internet]. 2020 [citado 2020 May 14]; 382(8): 727-733. Disponible en: https://www.nejm.org/doi/10.1056/NEJMoa2001017. https://doi.org/10.1056/NEJMoa2001017.
Jin Y, Cai L, Cheng Z, Cheng H, Deng T, Yi B, et al. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Military Med Res [Internet]. 2020 [citado 2020 May 15]; 7(4): 1-23. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32029004/. https://doi.org/10.1186/s40779-020-0233-6.
Organización Mundial de la Salud. Enfermedad por coronavirus 2019 (COVID-19): informe de situación, 41 [Internet]. Washington: OMS; 2020 [citado 2020 May 15]. Disponible en: https://apps.who.int/iris/handle/10665/331352.
Organización Mundial de la Salud. Enfermedad por coronavirus 2019 (COVID-19): informe de situación, 194 [Internet]. Washington: OMS; 2020 [citado 2020 May 15]. Disponible en: https://apps.who.int/iris/handle/10665/331352.
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA [Internet]. 2020 [citado 2020 May 16]; 323(11): 1061-1069. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32031570/. https://doi.org/10.1001/jama.2020.1585.
Wu P, Hao X, Lau E, Wong J, Leung K, Wu J, et al. Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020. Euro Surveill [Internet]. 2020 [citado 2020 May 16]; 25(3): 1-6. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31992388%/. https://doi.org/10.2807/1560-7917.ES.2020.25.3.2000044.
Wang C, Horby P, Hayden F, Gao G. A novel coronavirus outbreak of global health concern. The Lancet Infect Dis [Internet]. 2020 [citado 2020 May 16]; 395(10223): 470–473. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31986257/. https://doi.org/10.1016/S0140-6736(20)30185-9.
Frutos R, Lopez M, Serra J, Devaux C. COVID-19: The Conjunction of Events Leading to the Coronavirus Pandemic and Lessons to Learn for Future Threats. Front Med [Internet]. 2020 [citado 2020 May 16]; 7(223): 1-5. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235412/. https://doi.org/10.3389/fmed.2020.00223.
Afelt A, Devaux C, Serra J, Frutos R. Bats, Bat-Borne Viruses, and Environmental Changes. InTech [Internet]. 2018 [citado 2020 May 16]; 8: 113-132. Disponible en: https://www.intechopen.com/books/bats/bats-bat-borne-viruses-and-environmental-changes. https://doi.org/10.5772 / intechopen.74377.
Qiu Y, Zhao Y, Wang Q, Li J, Zhou Z, Liao C, et al. Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2. Microbes Infect [Internet]. 2020 [citado 2020 May 17]; 22(4-5): 221-225. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32199943/. https://doi.org/10.1016/j.micinf.2020.03.003.
Liu Y, Gong L, Li B. Epidemic Situation of Novel Coronavirus Pneumonia in China mainland. Epidemiology. medRxiv [Internet]. 2020 [citado 2020 May 17]. Disponible en: https://www.medrxiv.org/content/10.1101/2020.02.17.20024034v2. https://doi.org/10.1101/2020.02.17.20024034.
Lai S, Bogoch I, Ruktanonchai N, Watts A, Lu X, Yang W, et al. Assessing spread risk of Wuhan novel coronavirus within and beyond China, January-April 2020: a travel network-based modelling study. medRxiv [Internet]. 2020 [citado 2020 May 17]: 1-20. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32511631/. https://doi.org/10.1101/2020.02.04.20020479.
Dirección Nacional de Gestión de Riesgo del Ministerio de Salud Pública del Ecuador. Informe de Situación COVID-19 desde el 29 de Febrero del 2020. Report No: 001. Quito: MSP; 2020.
Ortiz E, Simbaña K, Barreno L, Díaz A, Barreto A, Moyano C, et al. Epidemiological, socio-demographic and clinical features of the early phase of the COVID-19 epidemic in Ecuador [Internet]. 2020 [citado 2020 May 17];15(1). Disponible en: https://pubmed.ncbi.nlm.nih.gov/33395425/. https://doi.org/10.1101/2020.05.08.20095943.
Torres I, Sacoto F. Localising an asset-based COVID-19 response in Ecuador. The Lancet Infect Dis [Internet]. 2020 [citado 2020 May 18]; 395(10233). Disponible en: https://pubmed.ncbi.nlm.nih.gov/32277877/. https://doi.org/10.1016 / S0140-6736(20)30851-5.
Amores C, Pérez G. La pertenencia étnica y el acceso a los servicios de salud: Caso de indígenas y afrodescendientes ecuatorianos en el periodo 2006-2015. Rev Publicando [Internet]. 2017 [citado 2020 May 18]; 4(11(1)): 618–638. Disponible en: https://revistapublicando.org/revista/index.php/crv/article/view/602.
Dirección Nacional de Gestión de Riesgo del Ministerio de Salud Pública del Ecuador. Situación Nacional por Covid-19 (Coronavirus) Ecuador 2020. Infografía No: 094. Quito: MSP; 2020.
Ngonghala C, Iboi E, Eikenberry S, Scotch M, MacIntyre C, Bonos M, et al. Mathematical assessment of the impact of non-pharmaceutical interventions on curtailing the 2019 novel Coronavirus. Math Biosci [Internet]. 2020 [citado 2020 May 18]; 325. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32360770/. https://doi.org/10.1016/j.mbs.2020.108364.
Li H, Liu S, Yu X, Tang S, Tang C. Coronavirus disease 2019 (COVID-19): current status and future perspectives. Int J Antimicrob Agents [Internet]. 2020 [citado 2020 May 19]; 55(5). Disponible en: https://pubmed.ncbi.nlm.nih.gov/32234466/. https://doi.org/10.1016/j.ijantimicag.2020.105951.
Koo J, Cook A, Park M, Sun Y, Sun H, Lim J, et al. Interventions to mitigate early spread of SARS-CoV-2 in Singapore: a modelling study. The Lancet Infect Dis [Internet]. 2020 [citado 2020 May 21]; 20(6): 678–688. Disponible en: https://www.thelancet.com/journals/lancet/article/PIIS1473-3099(20)30162-6/fulltext. https://doi.org/10.1016/S1473-3099(20)30162-6.
Lewnard J, Lo N. Scientific and ethical basis for social-distancing interventions against COVID-19. Lancet Infect Dis [Internet]. 2020 [citado 2020 May 19]; 20(6): 631-633. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32213329/. https://doi.org/1010.1016/S1473-3099(20)30190-0.
Nicola M, Alsafi Z, Sohrabi C, Kerwan A, Al-Jabir A, Iosifidis C, et al. The socio-economic implications of the coronavirus pandemic (COVID-19): A review. Int J Surg [Internet]. 2020 [citado 2020 May 20]; 78: 185-193. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32305533/. https://doi.org/10.1016/j.ijsu.2020.04.018.
McKee M, Stuckler D. If the world fails to protect the economy, COVID-19 will damage health not just now but also in the future. Nat Med [Internet]. 2020 [citado 2020 May 20]; 26(5): 640-642. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32273610/. https://doi.org/10.1038/s41591-020-0863-y.
Zhou P, Yang X, Wang X, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature [Internet]. 2020 [citado 2020 May 20]; 579(7798): 270-273. Disponible en: https://pubmed.ncbi.nlm.nih.gov/33199918/. https://doi.org/10.1038/s41586-020-2012-7.
Paraskevis D, Kostaki E, Magiorkinis G, Panayiotakopoulos G, Sourvinos G, Tsiodras S. Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event. Infect Genet Evol [Internet]. 2020 [citado 2020 May 20]; 79: 104212. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32004758/. https://doi.org/10.1016 /j.meegid.2020.104212.
Helmy Y, Fawzy M, Elaswad A, Sobieh A, Kenney S, Shehata A. The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control. J Clin Med [Internet]. 2020 [citado 2020 May 21]; 9(4). Disponible en: https://pubmed.ncbi.nlm.nih.gov/32344679/. https://doi.org/10.3390/jcm9041225.
Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The Lancet Infect Dis [Internet]. 2020 [citado 2020 May 21]; 395(10224): 565–574. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32007145/. https://doi.org/10.1016/S0140-6736(20)30251-8.
Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W, et al. Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses [Internet]. 2020 [citado 2020 May 21]; 12(4). Disponible en: https://pubmed.ncbi.nlm.nih.gov/32230900/. https://doi.org/10.3390/v12040372.
Chan J, Kok K, Zhu Z, Chu H, To K, Yuan S, et al. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect [Internet]. 2020 [citado 2020 May 21]; 9(1): 221–236. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31987001/. https://doi.org/10.1080/22221751.2020.1719902.
Li H, Liu S, Yu X, Tang S, Tang C. Coronavirus disease 2019 (COVID-19): current status and future perspectives. Int J Antimicrob Agents [Internet]. 2020 [citado 2020 May 22]; 55(5): Disponible en: https://pubmed.ncbi.nlm.nih.gov/32234466/. https://doi.org/105951.10.1016/j.ijantimicag.2020.105951.
Tang X, Wu C, Li X, Song Y, Yao X, Wu X, et al. On the origin and continuing evolution of SARS-CoV-2. National Science Review [Internet]. 2020 [citado 2020 May 22]; 7(6): 1012–1023. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7107875/. https://doi.org/10.1093/nsr/nwaa036.
Ludwig S, Zarbock A. Coronaviruses and SARS-CoV-2: A Brief Overview. Anesth Analg [Internet]. 2020 [citado 2020 May 22]; 131(1): 93-96. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32243297/. https://doi.org/10.1213/ANE.0000000000004845.
Andersen K, Rambaut A, Lipkin W, Holmes E, Garry R. The proximal origin of SARS-CoV-2. Nat Med [Internet]. 2020 [citado 2020 May 22]; 26(4): 450–452. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32284615/. https://doi.org/10.1038/s41591-020-0820-9.
Zhang T, Wu Q, Zhang Z. Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak. Current Biology [Internet]. 2020 [citado 2020 May 23]; 30(7): 1346-1351. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169893/. https://doi.org/10.1016/j.cub.2020.03.022.
Sheahan T, Rockx B, Donaldson E, Sims A, Pickles R, Corti D, et al. Mechanisms of Zoonotic Severe Acute Respiratory Syndrome Coronavirus Host Range Expansion in Human Airway Epithelium. J Virol [Internet]. 2008 [citado 2020 May 23]; 82(5): 2274-2285. Disponible en: https://pubmed.ncbi.nlm.nih.gov/18094188/. https://doi.org/10.1128/JVI.02041-07.
Scheller C, Krebs F, Minkner R, Astner I, Gil M, Wätzig H. Physicochemical properties of SARS‐CoV‐2 for drug targeting, virus inactivation and attenuation, vaccine formulation and quality control. Electrophoresis [Internet]. 2020 [citado 2020 May 23]; 41: 13-14. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32469436/. https://doi.org/10.1002/elps.202000121.
Yao Y, Pan J, Liu Z, Meng X, Wang W, Kan H, et al. No association of COVID-19 transmission with temperature or UV radiation in Chinese cities. Eur Respir J [Internet]. 2020 [citado 2020 May 24]; 55(5). Disponible en: https://pubmed.ncbi.nlm.nih.gov/32269084/. https://doi.org/10.1183/13993003.00517-2020.
Keil S, Ragan I, Yonemura S, Hartson L, Dart N, Bowen R. Inactivation of severe acute respiratory syndrome coronavirus 2 in plasma and platelet products using a riboflavin and ultraviolet light‐based photochemical treatment. Vox Sang [Internet]. 2020 [citado 2020 May 24]; 115(6): 495-501. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32311760/. https://doi.org/10.1111/vox.12937.
Bedell K, Buchaklian A, Perlman S. Efficacy of an Automated Multiple Emitter Whole-Room Ultraviolet-C Disinfection System Against Coronaviruses MHV and MERS-CoV. Infect Control Hosp Epidemiol [Internet]. 2016 [citado 2020 May 25]; 37(5): 598-599. Disponible en: https://pubmed.ncbi.nlm.nih.gov/26818469/. https://doi.org/10.1017/ice.2015.348.
Hamzavi I, Lyons A, Kohli I, Narla S, Parks A, Gelfand J, et al. Ultraviolet germicidal irradiation: Possible method for respirator disinfection to facilitate reuse during the COVID-19 pandemic. J Am Acad Dermatol [Internet]. 2020 [citado 2020 May 25]; 82(6): 1511-1512. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32246972/. https://doi.org/10.1016/j.jaad.2020.03.085.
Sagripanti J, Lytle C. Estimated Inactivation of Coronaviruses by Solar Radiation With Special Reference to COVID‐19. Photochem Photobiol [Internet]. 2020 [citado 2020 May 25]; 96(4): 731-737. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32502327/. https://doi.org/10.1111/php.13293.
Yi Y, Lagniton P, Ye S, Li E, Xu R. COVID-19: what has been learned and to be learned about the novel coronavirus disease. Int J Biol Sci [Internet]. 2020 [citado 2020 May 25]; 16(10): 1753-1766. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32226295/. https://doi.org/10.7150/ijbs.45134.
Liu Y, Gayle A, Wilder A, Rocklöv J. The reproductive number of COVID-19 is higher compared to SARS coronavirus. J Travel Med [Internet]. 2020 [citado 2020 May 26]; 27(2): 1-21. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32052846/. https://doi.org/10.1093/jtm/taaa021.
Bulut C, Kato Y. Epidemiology of COVID-19. Turk J Med Sci [Internet]. 2020 [citado 2020 May 26]; 50(SI-1): 563-570. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195982/. https://doi.org/10.3906/sag-2004-172.
D’Arienzo M, Coniglio A. Assessment of the SARS-CoV-2 basic reproduction number, R0, based on the early phase of COVID-19 outbreak in Italy. Salud de Biosaf [Internet]. 2020 [citado 2020 May 26]; 2(2): 57-59. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32835209/. https://doi.org/10.1016/j.bsheal.2020.03.004
Torres J, Kobiak C, Valcarcel B, Diaz C, La Vecchia C. The reproductive number R0 of COVID-19 in Peru: An opportunity for effective changes. Travel Med Infect Dis [Internet]. 2020 [citado 2020 May 27]; 37. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32325120/. https://doi.org/10.1016/j.tmaid.2020.101689.
Najafimehr H, Mohamed A, Safari S, Yousefifard M, Hosseini M. Estimation of basic reproduction number for COVID‐19 and the reasons for its differences. Int J Clin Pract [Internet]. 2020 [citado 2020 May 27]; 74(8). Disponible en: https://pubmed.ncbi.nlm.nih.gov/32301199/. https://doi.org/10.1111/ijcp.13518.
Cascella M, Rajnik M, Cuomo A, Dulebohn S, Di Napoli R. Features, Evaluation and Treatment Coronavirus (COVID-19). Stat Pearls [Internet]. 2020 [citado 2020 May 28]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32150360/.
McIntosh K. Coronavirus disease 2019 (COVID-19): Epidemiology, virology, clinical features, diagnosis, and prevention. UpToDate [Internet]. 2020 [citado 2020 May 29]. Disponible en: https://www.uptodate.com/contents/coronavirus-disease-2019-covid-19-epidemiology-virology-clinical-features-diagnosis-and-prevention.
Galbadage T, Peterson B, Gunasekera R. Does COVID-19 Spread Through Droplets Alone?. Frente a la Salud Pública [Internet]. 2020 [citado 2020 May 29]; 8. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32391310/. https://doi.org/10.3389/fpubh.2020.00163.
Doremalen N, Bushmaker T, Morris D, Holbrook M, Gamble A, Williamson B, et al. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N Engl J Med [Internet]. 2020 [citado 2020 May 30]: 382(16): 1564-1567. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32182409/. https://doi.org/10.1056/NEJMc2004973.