Quality of life in pediatric patients treated with chemotherapy for the diagnosis of acute lymphoblastic leukemia

Authors

DOI:

https://doi.org/10.37135/ee.04.13.04

Keywords:

Leukemia, Lymphoid, Quality of Life, Drug Therapy, Pediatrics

Abstract

Leukemia is a malignant neoplastic disease that constitutes a health problem that mainly affects children. Thus, this research aimed to describe the quality of life in pediatric ALL patients between 2 and 18 years of age, treated in 2019, at the Baca Ortiz Pediatric Hospital and at the Solca Hospital - Núcleo Quito, Ecuador. A cross-sectional, descriptive, and observational study with a quantitative approach. Data were collected by reviewing the medical records of the 60 patients in the research context. 66.7% were male, 43.3% were between 2 and 4 years old, 38.3% had fever as the initial symptom. Down syndrome was the most frequent comorbidity (6.7%). Type B ALL was diagnosed in 54 patients. 66.7% received psychological therapy. 22 of the patients were in the induction and maintenance phase. 65% dropped out of school while receiving chemotherapy. Those ones who considered their quality of life as good predominated, followed by those ones who were severely affected. The greatest effects on the participants were: difficulties with feeding, presence of pain, lack of communication, existence of anxiety and presence of stress due to worry due to the possible infectivity of the treatment.

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References

Mancero-Rodríguez MJ, Arellano-Salinas KP, Santo-Cepeda KA, Rodríguez-Revelo ME. Leucemia linfoblástica aguda diagnóstico. RECIMUNDO: Rev Cient de la Invest y el Conoc [Internet]. 2020 [citado 11 Abr 2021]; 4(2): 53-63. Disponible en: https://dialnet.unirioja.es/descarga/articulo/7591561.pdf.

Boyle P, Ferlay J. Cancer incidence and mortality in Europe. Annals of Oncol [Internet]. 2005 [citado 20 Dic 2020]; 16(3): 481-488. Disponible en: https://www.sciencedirect.com/science/article/pii/S0923753419478861. https://doi.org/10.1093/annonc/mdi098.

Lillo SL. El proceso de comunicar y acompañar a los padres y al paciente frente al diagnóstico de discapacidad. Rev Méd Clín Las Condes [Internet]. 2014 [citado 19 Dic 2019]; 25(2): 372-379. Disponible en: https://www.sciencedirect.com/science/article/pii/S0716864014700495. https://doi.org/10.1016/S0716-8640(14)70049-5.

Dorantes E, Villasís MÁ, Zapata M, Arias J, Escamilla A, Miranda AL et al. Calidad de vida de niños mexicanos con leucemia linfoblástica aguda atendidos por el Seguro Popular. Bol Méd del Hosp Infant de Méx [Internet]. 2012 [citado 17 Dic 2019]; 69(3): 242-254. Disponible en: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1665-11462012000300012.

Kamps WA, Van der Pal-de Bruin KM, Veerman AJ, Fiocco M, Bierings M, Pieters R. Long-term results of Dutch Childhood Oncology Group studies for children with acute lymphoblastic leukemia from 1984 to 2004. Leukemia [Internet]. 2010 [15 Ene 2020]; 24:309-319. Disponible en: https://www.nature.com/articles/leu2009258.

Margolin JF, Steuber CP, Poplack DG. Acute Lymphoblastic Leukemia. Principles and practice of pediatric oncology. En: Pizzo A, Poplack D. Eds. 6th edition. Philadelphia: Linpicott Lippincott Williams & Wilkins Publishers; 2011. p. 518-565.

Mostert S, Arora RS, Arreola M, Bagai P, Friedrich P, Gupta S, et al. Abandonment of treatment for childhood cancer: position statement of a SIOP PODC Working Group. Lancet Oncol [Internet]. 2011 [25 Ene 2020]; 12(8): 719-720. Disponible en: https://pubmed.ncbi.nlm.nih.gov/21719348/.

Rabin KR, Poplack DG. Management strategies in acute lymphoblastic leukemia. Oncology [Internet]. 2011 [citado 08 Ene 2020]; 25(4): 328-335. Disponible en: https://www.proquest.com/openview/c3494ded44c2c41b7dd678995e1bd75d/1?casa_token=jpmkfbYwYqAAAAAA:RdswcN7pPuj66o-RyksFGfTqd8MlCTiscnmWrsnQsL60W4lESaGJTrPIdvFU1UmV4uMdVmNhxQU&cbl=38461&pq-origsite=gscholar.

Salzer WL, Devidas M, Carroll WL, Winick N, Pullen J, Hunger SP, et al. Long-term results of the pediatric oncology group studies for childhood acute lymphoblastic leukemia 1984-2001: a report from the children’s oncology group. Leukemia [Internet]. 2010 [citado 17 Feb 2020]; 24: 355-370. Disponible en: https://www.nature.com/articles/leu2009261.

Sitaresmi MN, Mostert S, Gundy CM, Sutaryo, Veerman JP. Health-related quality of life assessment in Indonesian childhood acute lymphoblastic leukemia. Health Quality of Life Outcomes [Internet]. 2008 [citado 13 Feb 2020]; 6: 96-102. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613134/. https://doi.org/10.1186/1477-7525-6-96.

Smith MA, Ries LA, Gurney JG, et al. Leukemia. In: Ries LA, Smith MA, Gurney JG, et al. Cancer incidence and survival among children and adolescents. Bethesda: National Cancer Institute; 2015. p. 17-34.

Sung L, Yanofsky R, Klaassen RJ, Dix D, Pritchard S, Winick N, et al. Quality of life during active treatment for pediatric acute lymphoblastic leukemia. Int J Cancer [Internet]. 2011 [citado 06 Feb 2020]; 128(5):1213-1220. https://pubmed.ncbi.nlm.nih.gov/20473921/. https://doi.org/10.1002/ijc.25433.

Ramírez-Zamora LM, Llamas-Peregriana NE, Lona-Reyes JC, Sánchez-Zubieta FA. Calidad de vida en niños con cáncer mediante PedsQL Cancer Module©. Rev Mex Pediatr [Internet]. 2015 [citado 12 Feb 2020]; 82(2):49-56. Disponible en: https://www.medigraphic.com/pdfs/pediat/sp-2015/sp152c.pdf.

Halfon-Domenech C. Leucemia linfoblástica aguda del niño y el adolescente. EMC – Pediatría [Internet]. 2021 [citado 19 Jun 2021]; 56(1): 1-9. Disponible en: https://www.sciencedirect.com/science/article/pii/S1245178921447207. https://doi.org/10.1016/S1245-1789(21)44720-7.

Pena-Amaya P, Flores A, Christmann A, Detoni D, Drelichman G, Soberón B, et al. Feohifomicosis por Exserohilum rostratum en un paciente pediátrico con leucemia linfoblástica aguda postransplante de médula ósea. Rev Argentina Microbiol [Internet]. 2020 [citado 11 Jun 2021]; 52(3): 195-197. Disponible en: https://www.sciencedirect.com/science/article/pii/S0325754119301166. https://doi.org/10.1016/j.ram.2019.11.002.

Astolfo MF, Cañazares P, Majek E, Burgesserc V, Carusod M, Bascoe J, et al. Sinusitis aguda invasiva por Exserohilum rostratum en una paciente pediátrica con recaída medular de leucemia linfoblástica aguda. Arch Argent Pediatr [Internet]. 2018 [citado 04 Jun 2021]; 116(4): 594-598. Disponible en: https://www.sap.org.ar/docs/publicaciones/archivosarg/2018/v116n4a24.pdf. http://dx.doi.org/10.5546/aap.2018.e594.

Reyes-Baque J, Mendoza-Cedeño M, Pozo-Ramírez C. Prevalencia de leucemia linfoblástica aguda en niños: Análisis citogenético y valor pronóstico. Polo del Conocimiento [Internet]. 2021 [citado 27 Jun 2021]; 6(7): 346-377. Disponible en: https://polodelconocimiento.com/ojs/index.php/es/article/view/2854 http://dx.doi.org/10.23857/pc.v6i7.2854.

Jiménez-Morales S, Hidalgo-Miranda A, Ramírez-Bello J. Leucemia linfoblástica aguda infantil: una aproximación genómica. Boletín Méd del Hosp Infant de Méx [Internet]. 2017 [citado 11 Ago 2021]; 74(1): 13-26. Disponible en: https://www.sciencedirect.com/science/article/pii/S1665114617300060. https://doi.org/10.1016/j.bmhimx.2016.07.007.

Espinoza-Diaz CI, Villacrés-Peñafiel L, Caicedo-Peñafiel G, Herrera-Herrera M, Mayorga-Gutiérrez E, Cáceres-Paredes ÁE, et al. Leucemia linfoblástica aguda aguda y complicaciones neurológicas en niños y adolescentes. Arch Venezol de Farmacol y Terapéut [Internet]. 2019 [citado 12 Jul 2021]; 38(6): 761-776. Disponible en: https://www.redalyc.org/articulo.oa?id=55964142016.

Castro-Arechaga S, Ronceros-Salas L, Vega-Centeno S, Moreno M, Soto A. Sobrevida global y libre de enfermedad en una cohorte peruana de pacientes con leucemia linfoblástica aguda. Rev Peruana de Med Experim y Salud Púb [Internet]. 2018 [08 Ago 2021]; 35(3): 416-425. Disponible en: https://www.scielosp.org/article/rpmesp/2018.v35n3/416-425/#. https://doi.org/10.17843/rpmesp.2018.353.2947.

Calderón-Rodríguez SI, Umaña-Pérez A. Estudio proteómico 2DE-DIGE en plasma sanguíneo de pacientes en etapa infantil con leucemia linfoblástica aguda. Rev Colomb Quím [Internet]. 2019 [citado 19 Jul 2021]; 48(1): 5-15. Disponible en: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-28042019000100005. https://doi.org/10.15446/rev.colomb.quim.v48n1.75170.

Fuentes L, Flores M, Iglesias A, Luzuriaga A, Rendón N, Ordoñez R, et al. Características de la leucemia linfoblástica aguda y neutropenia febril en niños y adolescentes atendidos en un hospital de Guayaquil, Ecuador. Rev Peruana de Med Experim y Salud Púb [Internet]. 2018 [citado 03 Ago 2021]; 35(2): 272-278. Disponible en: https://www.scielosp.org/article/rpmesp/2018.v35n2/272-278/#. https://doi.org/10.17843/rpmesp.2018.352.2862.

Published

2022-01-11

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How to Cite

1.
García Ríos CA, Recalde Bermeo MR, Criollo Criollo A del R. Quality of life in pediatric patients treated with chemotherapy for the diagnosis of acute lymphoblastic leukemia. REE [Internet]. 2022 Jan. 11 [cited 2024 Nov. 24];16(1):29-38. Available from: https://eugenioespejo.unach.edu.ec/index.php/EE/article/view/436

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