Paget's bone disease, clinical case report
DOI:
https://doi.org/10.37135/ee.04.24.07Palabras clave:
Osteitis Deformans, Bone Remodeling, BisphosphonatesResumen
Paget's disease is a disorder affecting bone metabolism due to accelerated bone remodeling. It mainly affects the pelvis, spine, lower extremity bones, and skull. It is believed to be the result of a combination of genetic and environmental factors; its incidence has decreased in recent years. Symptoms are usually absent; however, some report bone pain. Treatment aimed to prevent bone remodeling by using bisphosphonates.
We present the case of a 34-year-old female with pain and bone deformity of the knee of 5 months of evolution, in radiographs and scintigraphy, with signs compatible with Paget's disease. Bisphosphonates were administered, and there was improvement after 3 months. This is a relevant case because the incidence of Paget's disease is higher in men over 40 years of age.
Descargas
Referencias
Singer FR. The evaluation and treatment of Paget's disease of bone. Best Pract Res Clin Rheumatol. 2020; [cited Jun 15, 2024]; 101506. Available at: https://www.sciencedirect.com/science/article/abs/pii/S1521694220300231 DOI: https://doi.org/10.1016/j.berh.2020.101506.
Ralston SH, Corral-Gudino L, Cooper C, et al. Diagnosis and management of Paget's disease of bone in adults: a clinical guideline. J Bone Miner Res. 2019; [cited 1 Jun 2024]; 34(4):579–604. Available from: https://academic.oup.com/jbmr/article/34/4/579/7606010 DOI: https://doi.org/10.1002/jbmr.3657 .
Rendina D, et al. Diagnosis and treatment of Paget's disease of bone: position paper from the Italian Society of Osteoporosis, Mineral Metabolism and Skeletal Diseases (SIOMMMS). J Endocrinol Invest . 2024; [cited 3 Jun 2024]; 47(6):1335–60. Available from: https://link.springer.com/content/pdf/10.1007/s40618-024-02318-1.pdf . DOI: https://doi.org/10.1007/s40618-024-02318-1.PMID:38488978.
Pariente A. Alkaline phosphatase. EMC - Tratado de Medicina. 2024; [cited 25 Jun 2024]; 28(3):1–5. Available from: https://www.sciencedirect.com/science/article/abs/pii/S1636541024492994 DOI: https://doi.org/10.1016/S1636-5410(24)49299-4.
Singer FR, Bone HG III, Hosking DJ, Lyles KW, Murad MH, Reid IR, Siris ES. Paget's disease of bone: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab . 2014; [cited 2 Jun 2024]; 99(12):4408–22. Available from: https://academic.oup.com/jcem/article/99/12/4408/2833929 DOI: https://doi.org/10.1210/jc.2014-2910 .
Menéndez-Bueyes LR, Soler Fernández MC. Paget's disease of bone: an approach to its historical origins. Reumatol Clin. 2017; [cited 6 Jun 2024]; 13(2):66–72. Available from: https://www.sciencedirect.com/science/article/abs/pii/S2173574317300011.
Choi YJ, Sohn YB, Chung YS. Updates on Paget's disease of bone. Endocrinol Metab (Seoul). 2022; [cited 24 Jun 2024]; 37(5):732–43. Available from: https://synapse.koreamed.org/articles/1516079575 DOI: https://doi.org/10.3803/EnM.2022.1575.PMID:36327984;PMCID:PMC9633214.
Alonso N, Calero-Paniagua I, del Pino-Montes J. Clinical and genetic advances in Paget's disease of bone: a review. Rev Osteoporos Metab Miner. 2017; [cited 8 Jun 2024]; 15(1):37–48. Available from: https://www.pure.ed.ac.uk/ws/portalfiles/portal/30397360/art_10.1007_s12018_016_9226_0.pdf . DOI: https://doi.org/10.1007/s12018-016-9226-0 .
Ralston SH, Layfield R. Pathogenesis of Paget disease of bone. Calcif Tissue Int. 2012; [cited 13 Jun 2024]; 91(2):97–113. Available from: https://www.researchgate.net/profile/Stuart-Ralston/publication/224867639_Pathogenesis_of_Paget_Disease_of_Bone/links/5761cd3808aeeada5bc501bd/Pathogenesis-of-Paget-Disease-of-Bone.pdf . DOI: https://doi.org/10.1007/s00223-012-9599-0 .
Chung PYJ, Beyens G, Boonen S, Papapoulos S, Geusens P, Karperien M, et al. Most of the genetic risk for Paget's disease of bone is explained by genetic variants near the CSF1, OPTN, TM7SF4, and TNFRSF11A genes. Hum Genet. 2010; [cited 11 Jun 2024]; 128(6):615–26. Available from: https://ris.utwente.nl/ws/portalfiles/portal/6834764/Chung10majority.pdf . DOI: https://doi.org/10.1007/s00439-010-0888-2 .
Maatallah K, Ben Nessib D, Labbène E, Ferjani H, Bouaziz M, Kaffel D, et al. Paget's disease of bone in patients under 40 years: two case reports and review of the literature. Sultan Qaboos Univ Med J. 2021; [cited 12 Jun 2024]; 21(1):e127–31. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC7968898/pdf/squmj2102-e127-131.pdf . DOI: https://doi.org/10.18295/squmj.2021.21.01.019.
Wang QY, Fu SJ, Ding N, Liu SY, Chen R, Wen ZX, et al. Clinical features, diagnosis and treatment of Paget's disease of bone in mainland China: a systematic review. Rev Endocr Metab Disord. 2020; [cited 7 Jun 2024]; 21(4):645–55. Available from: https://link.springer.com/article/10.1007/s11154-020-09544-x . DOI: https://doi.org/10.1007/s11154-020-09544-x.
Ralston SH, Layfield R. Pathogenesis of Paget disease of bone. Calcif Tissue Int. 2012; [cited 13 Jun 2024]; 91(2):97–113. Available from: https://www.researchgate.net/profile/Stuart-Ralston/publication/224867639_Pathogenesis_of_Paget_Disease_of_Bone/links/5761cd3808aeeada5bc501bd/Pathogenesis-of-Paget-Disease-of-Bone.pdf . DOI: https://doi.org/10.1007/s00223-012-9599-0 .
Rodriguez J. Drug-induced osteonecrosis: benefit/risk profile of bisphosphonate use [online thesis]. Valladolid: University of Valladolid; 2021. Available from: https://uvadoc.uva.es/handle/10324/1757.
Escobar López EA, López López J, Marques Soares MS, Chimenos Küstner E. Bisphosphonate-associated osteonecrosis of the jaw: a systematic review. Odontoestomatol. 2007; [cited 14 Jun 2024]; 23(2). Available from: https://scielo.isciii.es/pdf/odonto/v23n2/original4.pdf.
Corral Gudiño L. Paget's disease of bone: 1877–2023. Etiology and approach to a disease in epidemiological transition. Med Clin (Barc). 2023; [cited 16 Jun 2024]; 161(5):207–16. Available from: https://www.sciencedirect.com/science/article/pii/S0025775323002592 DOI: https://doi.org/10.1016/j.medcli.2023.05.005.
Rianon NJ, Bordes JK. Paget disease of bone for primary care. A.M APm Physician. 2020; [cited 19 June 2024]; 102(4):224–8. Available from: https://www.aafp.org/pubs/afp/issues/2020/0815/p224.pdf.
Lee JK, Kang YK, Wang PW, Hong SM. Paget's disease of bone affecting peripheral limb: difficulties in diagnosis: a case report. J Bone Metab . 2020; [cited 20 Jun 2024]; 27:71–5. Available from: https://ubmed.ncbi.nlm.nih.gov/32190611/
Tan A, Ralston SH. Clinical presentation of Paget's disease: evaluation of a contemporary cohort and systematic review. Calcif Tissue Int . 2014; [cited 23 Jun 2024]; 95:385–92. Available from: https://www.proquest.com/docview/1609058381?pq-origsite=gscholar&fromopenview=true&sourcetype=Scholarly%20Journals.
D. Merlotti, L. Gennari, G. Martini, F. Valleggi , V. De Paola, A. Avanzati , R. Nuti, Comparison of different intravenous bisphosphonate regimens for Paget 's disease of bone, J. Bone Miner. Res. [cited 3 Jun 2024]; 22 (10) (2007) 1510 – 1511. Available at: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1359/jbmr.070704.
Publicado
Número
Sección
Licencia
Derechos de autor 2025 Revista Eugenio Espejo
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.
