Uso de cannabinoides en el tratamiento de síntomas neuropsiquiátricos de la demencia: revisión sistemática
DOI:
https://doi.org/10.37135/ee.04.17.10Palabras clave:
demencia, cannabinoides, marihuana medicinalResumen
La demencia es un trastorno neurodegenerativo progresivo y crónico que produce síntomas neuropsiquiátricos (TNS) asociados. Se realizó una revisión sistemática de ensayos clínicos publicados en PubMed y Web of Science entre 1996 y 2022, utilizando la metodología PRISMA. Al finalizar el proceso de cribado, siete artículos resultaron los que cumplieron con los requerimientos establecidos. Los resultados de cinco estudios revisados mostraron la constatación de reducción de los TNS. No se reportaron eventos adversos graves en ninguno de los estudios, existiendo solo leves y moderados. Tampoco, se pudo identificar una estandarización de la dosis de cannabinoides en el tratamiento de los TNS; aunque, se observó una reducción en las escalas neuropsiquiátricas al utilizar dosis de nabilona de 1-2 mg/día. Los resultados analizados no permitieron establecer diferencias significativas a favor de alguno de los cannabinoides.
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